Differences in characteristics between Afghani and Iranian patients with pulmonary tuberculosis

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• 作者：Mehdi Seyed Mirsaeidi ; Payam Tabarsi ; Kaveh Khoshnood ; Ali Rowhani-Rahbar ; Omid Radpour ; Parisa Farnia ; Golnaz Ebrahimi ; Davood Mansouri ; Majid Amiri ; Zarnaz Bagheri ; Ali Akbar Velayati
• 关键词：EBV load ; Blood compartments ; HIV-infected population ; Brain lymphoma
• 刊名：International Journal of Infectious Diseases
• 出版年：2007
• 出版时间：March 2007
• 年：2007
• 卷：11
• 期：2
• 页码：180-182
• 全文大小：70 K

文摘

To analyze Epstein–Barr virus (EBV) load at different HIV infection stages and its relation with brain lymphoma.

Design

A cross-sectional study was conducted on 172 HIV-infected individuals: 62 asymptomatic HIV carriers (group A), 30 HIV progressors (group B), 73 AIDS patients (group C), seven AIDS patients with brain lymphoma (group C-BL); and 26 blood donors (group BD) as healthy carriers. EBV load was measured in peripheral blood mononuclear cells (PBMC) and plasma samples using a semi-quantitative PCR method.

Results

PBMC-EBV levels in HIV-infected patients were higher than in the blood donors (p < 0.05). No differences in PBMC-EBV loads were found in groups A, B, or C (p > 0.05), while the C-BL group had significantly lower levels (p < 0.05). Similar PBMC-EBV loads were seen in HIV-infected patients with CD4+ T cell counts higher than 50/mm³ (p > 0.05), while significantly lower levels were found in cases with less than 50 cells/mm³ (p < 0.05). In all HIV-infected patients, plasma-EBV load was lower than, or similar to, PBMC-EBV load, unlike 2/7 HIV-positive brain lymphoma patients.

Conclusions

During HIV infection PBMC-EBV load rises in comparison to healthy carriers, but decreases when immunosuppression progresses and CD4+ T cell count becomes <50/mm³. Circulating EBV is mainly cell-associated in the HIV-infected population. Neither PBMC-EBV nor plasma-EBV loads would be useful to diagnose brain lymphoma in AIDS patients.