Transcriptomic profile of Manila clam (Ruditapes philippinarum) haemocytes in response to Perkinsus olseni infection

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• 作者：Abul Farah Md. Hasanuzzaman^a ; ^b ; ^{mhzaman.bd@gmail.com} ; Diego Robledo^c ; ^{diego.robledo@usc.es} ; Antonio Gó ; mez-Tato^d ; ^{antonio.gomez.tato@usc.es} ; Jose A. Alvarez Dios^e ; ^{joseantonio.alvarez.dios@usc.es} ; Peter W. Harrison^f ; ^{p.w.harrison@ucl.ac.uk} ; Asunció ; n Cao^g ; ^{asun@cimacoron.org} ; Sergio Ferná ; ndez-Boo^g ; ^{fernandezboo.sergio@gmail.com} ; Antonio Villalba^g ; ^h ; ^{antonio.villalba.garcia@xunta.es} ; Belé ; n G. Pardo^a ; ^{belen.gomez@usc.es} ; Paulino Martí ; nez^a ; ^{paulino.martinez@usc.es}
• 关键词：AIP ; Apoptosis Inhibitor Protein ; BIRC ; Baculoviral Iap Repeat-Containing protein ; Bp ; base pair ; BP ; Biological Process ; CC ; Cellular Component ; DEGs ; Differentially Expressed Genes ; ECP ; Extracellular Product ; FC ; Fold Change ; FDR ; False Discovery Rate ; FPKM ; Fragments Per Kilobase of transcript per Million mapped reads ; FSW ; Filtered Sea Water ; GO ; Gene Ontology ; HSP ; Heat Shock Proteins ; IVT ; in vitro ; IVVI ; in vivo indoor ; IVVN ; in vivo natural ; MF ; Molecular Function ; PE ; Paired-End ; RNA-s
• 刊名：Aquaculture
• 出版年：2017
• 出版时间：20 January 2017
• 年：2017
• 卷：467
• 期：Complete
• 页码：170-181
• 全文大小：1452 K
• 卷排序：467

文摘

Manila clam haemocyte transcriptome was elucidated using RNA-seq from a diverse set of Perkinsus olseni challenges. Sequences were annotated by BLASTx and we detected 3642 DEGs (812 up- and 2830 down-regulated). DEGs were mainly related to binding and transport, signalling, proteolysis, stress and immune response. Results increase our knowledge of the genetic response of Manila clam to perkinsosis for controlling this parasitosis.