Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula
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- 作者：Hans-Gert Bernsteina ; hans-gert.bernstein@med.ovgu.de" class="auth_mail" title="E-mail the corresponding author ; Jens Hildebrandta ; Henrik Dobrowolnya ; Johann Steinera ; Bernhard Bogertsa ; Jens Pahnkeb ; c ; d
- 关键词：ABCB1 ; ATP-binding cassette ; subfamily B member 1 ; ANCOVA ; analysis of covariance ; CD-243 ; cluster of differentiation 243 ; CG ; cingulate gyrus ; CNS ; central nervous system ; DG ; dentate gyrus ; DSM-IV ; Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) ; Hb ; habenula ; INF ; interferon ; ITG ; inferior temporal gyrus ; MTG ; medial temporal gyrus ; kDa ; kilodalton ; le ; left ; Il ; interleukin ; MDR1 ; multidrug resistance protein 1 ; ri ; right ; Wm ; whiter matter
- 刊名：Schizophrenia Research
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：177
- 期：1-3
- 页码：52-58
- 全文大小：1036 K
文摘
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The ATP cassette transporter ABCB1 is regarded to be involved in schizophrenia.
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We immunolocalized ABCB1 protein expression in twelve brain regions of patients with schizophrenia and control cases.
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ABCB1 is located in multiple brain vessels and at habenular neurons known for purinergic neurotransmission.
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Morphometric analysis revealed decreased expression of ABCB1 in habenular microvasculature and neurons in schizophrenia.