Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway

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• 作者：H. Maldonado^a ; ^b ; C. Calderon^a ; F. Burgos-Bravo^a ; ^b ; O. Kobler^d ; W. Zuschratter^d ; O. Ramirez^b ; ^c ; S. Hä ; rtel^b ; ^c ; P. Schneider^e ; A.F.G. Quest^a ; R. Herrera-Molina^d ; ¹ ; ^{rherrera@lin-magdeburg.de} ; L. Leyton^a ; ^b ; ¹ ; ^{lleyton@med.uchile.cl}
• 关键词：CAMs ; cell adhesion molecules ; CM ; centers of mass ; CBP ; C-terminal Src kinase (Csk)-binding protein ; ECM ; extracellular matrix ; GPI ; glycosylphosphatidylinositol ; GFP ; green fluorescent protein ; MLCII ; myosin light chain II ; ROCK ; Rho-associated protein kinase ; SFKs ; Src family kinases ; STED ; stimulated emission depletion
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1864
• 期：2
• 页码：243-254
• 全文大小：1839 K
• 卷排序：1864

文摘

Astrocyte αvβ3 integrin engages neuronal Thy-1 in trans to induce neurite shortening. Neuronal β3 integrin Thy-1 cis interaction appears dispensable for neurite retraction. αvβ3 stimulation of Thy-1 in trans clusters Thy-1/CBP/Csk in a multi-protein complex CBP is a transmembrane transducer for Thy-1 signaling in neurons. Integrin-Thy-1 binding induces neurite retraction by inhibiting Src and activating RhoA.