Combinatorial Gene Regulation through Kinetic Control of the Transcription Cycle

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• 作者：Clarissa Scholes¹ ; ² ; Angela H. DePace¹ ; ^{angela_depace@hms.harvard.edu} ; Á ; lvaro Sá ; nchez³ ; ⁴ ; ⁵ ; ^{alvaro.sanchez@yale.edu}
• 关键词：transcription ; kinetics ; combinatorial control ; frequency modulation ; quantitative modeling ; Boolean computations
• 刊名：Cell Systems
• 出版年：2017
• 出版时间：25 January 2017
• 年：2017
• 卷：4
• 期：1
• 页码：97-108.e9
• 全文大小：3741 K
• 卷排序：4

文摘

We present a model for kinetic control of the transcription cycle Kinetic control captures how TFs can work together without physical interactions This model enables a broad range of logical and analog computations We suggest specific experiments to test the role of kinetic control in transcription