Functional and evolutionary analyses on expressed intronless genes in the mouse genome

详细信息    查看全文

• 作者：Kishore Ramaji Sakharkar ; Meena Kishore Sakharkar ; Cymbeline T. Culiat ; Vincent T.K. Chow and Shazib Pervaiz
• 关键词：Intronless ; Single exonic genes ; Housekeeping ; Ortholog ; Mouse models ; Human disease
• 刊名：FEBS Letters
• 出版年：2006
• 出版时间：20 February 2006
• 年：2006
• 卷：580
• 期：5
• 页码：1472-1478
• 全文大小：428 K

文摘

Using computational approaches we have identified 2017 expressed intronless genes in the mouse genome. Evolutionary analysis reveals that 56 intronless genes are conserved among the three domains of life – bacteria, archea and eukaryotes. These highly conserved intronless genes were found to be involved in essential housekeeping functions. About 80 % of expressed mouse intronless genes have orthologs in eukaryotic genomes only, and thus are specific to eukaryotic organisms. 608 of these genes have intronless human orthologs and 302 of these orthologs have a match in OMIM database. Investigation into these mouse genes will be important in generating mouse models for understanding human diseases.