Relationship between coumarin-induced hepatocellular toxicity and mitochondrial function in rats
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- 作者：Yasuhiro Tanakaa ; b ; Wataru Fujiia ; Hisako Horia ; Yoshinori Kitagawaa ; Kiyokazu Ozakib ; ozaki@pharm.setsunan.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Rat ; Coumarin ; Hepatotoxicity ; Mitochondria ; CYP2E1 ; Subcellular localization
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：90
- 期：Complete
- 页码：1-9
- 全文大小：5038 K
文摘
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Analyses of the mechanism of coumarin-induced hepatotoxicity were performed in rats.
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The liver mitochondrial function was primarily evaluated.
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Changes were observed in mitochondria before hepatocellular necrosis was evident.
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Repeated dosing increased extra-mitochondrial distribution of CYP2E1.
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Mitochondria and CYP2E1 may be involved in coumarin-induced hepatotoxicity.