Inheritance of a Nuclear PIWI from Pluripotent Stem Cells by Somatic Descendants Ensures Differentiation by Silencing Transposons in Planarian
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- 作者：Norito Shibata1 ; 4 ; shiba@mdb.biophys.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Makoto Kashima1 ; 4 ; Taisuke Ishiko1 ; Osamu Nishimura1 ; 2 ; Labib Rouhana1 ; 5 ; Kazuyo Misaki2 ; Shigenobu Yonemura2 ; Kuniaki Saito3 ; Haruhiko Siomi3 ; Mikiko C. Siomi3 ; 6 ; Kiyokazu Agata1 ; agata@mdb.biophys.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：9 May 2016
- 年：2016
- 卷：37
- 期：3
- 页码：226-237
- 全文大小：4837 K
文摘
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Three PIWI proteins temporally switch to repress TE during PSC differentiation
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Nuclear DjPiwiB is required for differentiation of neoblasts (PSCs) in planarian
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Depletion of DjPiwiB causes activation of TEs in somatic descendants of neoblasts
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DjPiwiB produced in neoblasts is inherited and acts in their somatic descendants