Differential contribution of three immune checkpoint (VISTA, CTLA-4, PD-1) pathways to antitumor responses against squamous cell carcinoma
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- 作者：Yuta Kondoa ; b ; Tatsukuni Ohnoa ; Naoto Nishiia ; Kiyoshi Haradab ; Hideo Yagitac ; Miyuki Azumaa ; miyuki.mim@tmd.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：CTLA-4 ; Head and neck squamous cell carcinoma ; Immune checkpoint inhibitor ; Immunotherapy ; PD-1 ; Tumor microenvironment ; VISTA
- 刊名：Oral Oncology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：57
- 期：Complete
- 页码：54-60
- 全文大小：1249 K
文摘
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VISTA blockade increases T cell recruitment in the tumor microenvironment.
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VISTA blockade converts CD8+ T cells to finally differentiated effector T cells.
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VISTA blockade enhances multifuntionality of CD8+ T cells.
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Combined CTLA-4 and VISTA blockade is more efficacious.
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Inhibition of regulatory T cell recruitment within tumors is critical.