Nonhydrolyzable C-disaccharides, a new class of DC-SIGN ligands
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- 作者：Benedetta Bertolottia ; Beá ; ta Oroszová ; a ; Ieva Sutkeviciuteb ; c ; d ; 1 ; Ladislav Kniežoa ; Franck Fieschib ; c ; d ; Kamil Parkana ; Zuzana Lovyová ; a ; Martina Ka&scaron ; á ; ková ; a ; Jitka Moravcová ; a ; Jitka.Moravcova@vscht.cz" class="auth_mail" title="E-mail the corresponding author
- 关键词：DC-SIGN ligands ; Glycomimetics ; C-Disaccharides ; Surface plasmon resonance
- 刊名：Carbohydrate Research
- 出版年：2016
- 出版时间：29 November 2016
- 年：2016
- 卷：435
- 期：Complete
- 页码：7-18
- 全文大小：956 K
文摘
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A set of eight original C-disaccharides based on d-mannose or l-fucose scaffold was synthesized.
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Their affinity to DC-SIGN ECD was evaluated by a SPR competition assay.
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C-Disaccharides were shown for the first time to be efficient antagonist of DC-SIGN receptor.
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l-Fucose glycomimetics open the space for the development of strong binding ligands.
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Stable C-glycoside ligands are attractive candidates for the construction of multivalent systems.