Repetitive shock wave therapy improves muscular microcirculation

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• 作者：Tobias Kisch ; MD^a ; ¹ ; ^{tobias.kisch@gmx.de" class="auth_mail" title="E-mail the corresponding author} ; Waldemar Wuerfel ; MD^b ; ¹ ; Vinzent Forstmeier ; MD^c ; Eirini Liodaki ; MD^a ; Felix H. Stang ; MD^a ; Karsten Knobloch ; PhD^d ; Peter Mailaender ; PhD^a ; Robert Kraemer ; PhD^a
• 关键词：Repetitive shockwave therapy ; ESWT ; Muscular microcirculation
• 刊名：Journal of Surgical Research
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：201
• 期：2
• 页码：440-445
• 全文大小：301 K

文摘

Extracorporeal shock wave therapy (ESWT) is mainly applied in tendon as well as bone problems based on stem-cell activation and healing acceleration. The effect of ESWT on muscle tissue is much less understood to date. However, from a clinical perspective, muscle injuries are of distinct interest especially in elite athletes such as soccer players.

ec_2">Material and methods

A total of 26 rats were randomized into two groups. Group A received a single application of high-energetic focused ESWT (0.3 mJ/mm², 4 Hz, 1000 impulses, 10 J), whereas group B underwent the same procedure every 10 min for three sessions (3 × 0.3 mJ/mm², 4 Hz, 3 × 1000 impulses, totaling 30 J). Blood flow at a depth of 8 mm was measured continuously and noninvasively by a combined Laser-Doppler-Imaging and photospectrometric technique (Oxygen-to-see, O2C, LEA Medizintechnik, Germany).

ec_3">Results

One minute after the application of high-energy ESWT blood flow in group A increased by 16.5% (<em>Pem> = 0.007). Thereafter, it decreased from minute 2 after application and remained significantly unchanged to baseline value until the end of the measuring period at 50 min (<em>Pem> = 0.550). Group B showed a similar significant increase in blood flow of 16.4% (<em>Pem> = 0.049) and a decrease afterward, too. After the second focused ESWT blood flow was boosted to 26.6% (<em>Pem> = 0.004), remaining significantly elevated until the third application was initiated. Muscular blood flow was increased to 29.8% after the third focused ESWT (<em>Pem> < 0.001), remaining significantly increased for another 10 min.

ec_4">Conclusions

Focused ESWT enhances blood flow in the muscle of rats. Moreover, repetitive ESWT extended this beneficial effect.