Non-alcoholic steatohepatitis: The role of oxidized low-density lipoproteins

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• 作者：Sofie M.A. Walenbergh¹ ; Ger H. Koek² ; Veerle Bieghs¹ ; Ronit Shiri-Sverdlov¹ ; ^{r.sverdlov@maastrichtuniversity.nl}
• 关键词：acLDL ; acetylated low-density lipoprotein ; AGEs ; advanced glycation end products ; ALP ; alkaline phosphatase ; ALT ; alanine transaminase ; AST ; aspartate transaminase ; BMI ; body mass index ; CCL23 ; chemokine C&ndash ; C motif ligand 23 ; CVD ; cardiovascular dise
• 刊名：Journal of Hepatology
• 出版年：2013
• 出版时间：April, 2013
• 年：2013
• 卷：58
• 期：4
• 页码：801-810
• 全文大小：968 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferencesn=""1.0"" encoding=""UTF-8""?><h3 class=""h3"">Summaryh3>Non-alcoholic steatohepatitis (NASH) is hallmarked by lipid accumulation in the liver (steatosis) along with inflammation (hepatitis). The transition from simple steatosis towards NASH represents a key step in pathogenesis, as it will set the stage for further severe liver damage. Yet, the pathogenesis behind hepatic inflammation is still poorly understood. It is of relevance to better understand the underlying mechanisms involved in NASH in order to apply new knowledge to potential novel therapeutic approaches. In the current review, we propose oxidized cholesterol as a novel risk factor for NASH. Here, we summarize mouse and human studies that provide possible mechanisms for the involvement of oxidized low-density lipoproteins in NASH and consequent potential novel diagnostic tools and treatment strategies for hepatic inflammation.