BMP-6 modulates somatostatin effects on luteinizing hormone production by gonadrotrope cells
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- 作者：Kishio Tomaa ; Fumio Otsukab ; fumiotsu@md.okayama-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kohei Ogunia ; b ; Tomohiro Terasakaa ; Motoshi Komatsubaraa ; Naoko Tsukamoto-Yamauchia ; Kenichi Inagakia ; Hirofumi Makinoc
- 关键词：ActRІІ ; activin type ІІ receptor ; ALK ; activin receptor-like kinase ; BMP ; bone morphogenetic protein ; BMPRІІ ; BMP type ІІ receptor ; ERK ; extracellular signal-regulated kinase ; FSH ; follicle-stimulating hormone ; GnRH ; gonadotropin-releasing hormone ; LH ; luteinizing hormone ; MAPK ; mitogen-activated protein kinase ; SAPK ; stress-activated protein kinase ; SSTR ; somatostatin receptor ; TGF-β ; transforming growth factor-β
- 刊名：Peptides
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：76
- 期：Complete
- 页码：96-101
- 全文大小：1068 K
文摘
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BMP-6 enhanced inhibitory effects of somatostatin analogs on LH secretion by upregulating SSTR5.
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Somatostatin analogs suppressed GnRH-induced ERK phosphorylation in the presence of BMP-6.
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Somatostatin analogs impaired Smad signaling by regulating BMPR and inhibitory Smad expression.
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BMP-6 modulates responsiveness of somatostatin analogs on LH production by gonadotrope cells.