Dickkopf-4 is frequently down-regulated and inhibits growth of colorectal cancer cells
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- 作者：Sebastian Baehs ; Andreas Herbst ; Susanne E. Thieme ; Claudia Perschl ; Andrea Behrens ; Silvio Scheel ; Andreas Jung ; Thomas Brabletz ; Burkhard Gö ; ke ; Helmut Blum ; Frank T. Kolligs
- 关键词：β ; -catenin ; Wnt ; Dickkopf ; DKK4 ; Colorectal cancer
- 刊名：Cancer Letters
- 出版年：2009
- 出版时间：18 April 2009
- 年：2009
- 卷：276
- 期：2
- 页码：152-159
- 全文大小：515 K
文摘
Like Dickkopf-1 (DKK1), DKK4 is a target of β-catenin/Tcf-4 in colorectal cancer. However, as a negative regulator of Wnt signalling its function in colorectal cancer cells is not well understood. We report that DKK4 is frequently down-regulated in colorectal cancer cell lines with deregulated β-catenin/Tcf-4 and in primary colorectal cancers. Exposure of cancer cells to DKK4 strongly inhibits basal β-catenin/Tcf-4 signalling activity, cancer cell growth and cell cycle progression. Therefore, loss of this negative feed-back loop provides Wnt factor expressing cancer cells with a growth advantage. Our data demonstrate that DKK4 is an important negative regulator of colon cancer cell growth.