Imipramine ameliorates early life stress-induced alterations in synaptic plasticity in the rat lateral amygdala
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- 作者：Joanna Danielewicza ; Aleksandra Trenka ; Grzegorz Hessa ; b ; grzegorz.hess@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author ; hess@if-pan.krakow.pl" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACSF ; artificial cerebrospinal fluid ; FP ; field potential ; IMI ; imipramine ; LA ; lateral amygdala ; LFS ; low frequency stimulation ; LTD ; long-term depression ; LTP ; long-term potentiation ; MS ; maternal separation ; PND ; postnatal day ; TBS ; theta burst stimulation
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：319-326
- 全文大小：1716 K
文摘
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Maternal separation stress reduced both LTP and LTD at the thalamic input to the lateral amygdala.
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Maternal separation stress impaired LTP and enhanced LTD at the cortical input to the lateral amygdala.
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Treatment with imipramine restored the extent of the synaptic modification range at the thalamic input.
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Treatment with imipramine restored the potential for LTD, but not for LTD, at the cortical input.
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Imipramine-mediated restoration of synaptic plasticity will have consequences for amygdala-dependent learning.