Endothelial dysfunction: Causes and consequences in patients with diabetes mellitus

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• 作者：Angelo Avogaro ; Saula Vigili de Kreutzenberg ; GianPaolo Fadini
• 关键词：Diabetes ; Endothelium ; Oxidative stress ; Endothelium progenitor cells
• 刊名：Diabetes Research and Clinical Practice
• 出版年：2008
• 出版时间：15 December 2008
• 年：2008
• 卷：82
• 期：Supplement 2
• 页码：S94-S101
• 全文大小：349 K

文摘

Vascular endothelium plays a major role in maintaining cardiovascular homeostasis. Nitric oxide is the most powerful vasodilating compound. Diabetes disrupts endothelial integrity through an increased oxidative stress. Recent evidence indicates that there is a strong interaction between diabetes, the secretory proteins of adipocytes, called adipokines, and endothelium. Endothelial dysfunction may precede the development of overt DM, and a prolonged and repeated exposure to postprandial hyperglycemia may play an important role in the development of atherosclerosis, even in those who have normal fasting plasma glucose levels.