Coupling of Homologous Recombination and the Checkpoint by ATR

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• 作者：Ré ; mi Buissonp>1p> ; Joshi Nirajp>2p> ; Amé ; lie Rodriguep>2p> ; Chu Kwen Hop>1p> ; Johannes Kreuzerp>1p> ; Tzeh Keong Foop>3p> ; Emilie J.-L. Hardyp>1p> ; Graham Dellairep>4p> ; Wilhelm Haasp>1p> ; Bing Xiap>3p> ; Jean-Yves Massonp>2p>p> ; p>p>jean-yves.masson@crchudequebec.ulaval.cap> ; Lee Zoup>1p>p> ; p>p>5p>p> ; p>p>6p>p> ; p>p>zou.lee@mgh.harvard.edup>
• 关键词：ATR ; PALB2 ; BRCA1 ; CDK ; checkpoint ; homologous recombination
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：19 January 2017
• 年：2017
• 卷：65
• 期：2
• 页码：336-346
• 全文大小：3014 K
• 卷排序：65

文摘

ATR acts after DNA end resection to promote HR The CDK-to-ATR switch after resection is important for efficient HR ATR promotes the BRCA1-PALB2 interaction and PALB2 localization to DSBs ATR regulates PALB2 by driving a phosphorylation switch on S59 and S64