Recombinant factor VIII Fc (rFVIIIFc) fusion protein reduces immunogenicity and induces tolerance in hemophilia A mice
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- 作者：Sriram Krishnamoorthya ; sriram.krishnamoorthy@biogen.com" class="auth_mail" title="E-mail the corresponding author ; Tongyao Liua ; Douglas Dragera ; Susannah Patarroyo-Whitea ; Ekta Seth Chhabraa ; Robert Petersa ; Neil Josephsonb ; David Lillicrapc ; Richard S. Blumbergd ; Glenn F. Piercea ; Haiyan Jianga ; haiyan.jiang.b@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：FVIII ; factor VIII ; rFVIIIFc ; recombinant human factor VIII Fc ; BDD ; B-domain deleted ; FL-rFVIII ; full length recombinant factor VIII ; Treg ; regulatory T-cells ; TNF-α ; tumor necrosis factor-α ; IFN-γ ; Interferon-γ
- 刊名：Cellular Immunology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：301
- 期：Complete
- 页码：30-39
- 全文大小：1677 K
文摘
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Therapeutic doses of rFVIIIFc elicited lower FVIII antibody responses in Hem A mice.
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rFVIIIFc induced tolerance to rFVIII and up-regulated key tolerogenic molecules.
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rFVIIIFc induced tolerance may involve Fc receptors FcRn and FcγR.