Dynein Clusters into Lipid Microdomains on Phagosomes to Drive Rapid Transport toward Lysosomes
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- 作者：Ashim Rai1 ; 2 ; Divya Pathak1 ; 2 ; Shreyasi Thakur1 ; Shampa Singh1 ; Alok Kumar Dubey1 ; Roop Mallik1 ; roop@tifr.res.in" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：11 February 2016
- 年：2016
- 卷：164
- 期：4
- 页码：722-734
- 全文大小：2947 K
文摘
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Dynein clusters into lipid microdomains on the phagosome as it matures
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Clustering allows many dyneins to simultaneously contact a single microtubule
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Large cooperative forces can now be generated to transport phagosomes to lysosomes
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Leishmania lipophosphoglycans disrupt microdomains and inhibit this transport