Levetiracetam prophylaxis ameliorates seizure epileptogenesis after fluid percussion injury
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- 作者：Yuan-Hao Chena ; chenyh178@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Eagle Yi-Kung Huangb ; 1 ; Tung-Tai Kuoc ; Barry J. Hofferd ; a ; f ; Pei-Jie Wub ; Hsin-I Maa ; Jing-Jr Tsaia ; Yu-Ching Choue ; Yung-Hsiao Chiangf
- 关键词：Traumatic brain injury ; Seizures ; Levetiracetam
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：1642
- 期：Complete
- 页码：581-589
- 全文大小：3212 K
文摘
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Moderate fluid percussion injury (FPI) augments seizure severity.
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Early post-traumatic seizures exacerbate consequent seizure severity.
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Prophylactic Levetiracetam reduces post-FPI seizure severity.
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Early post-FPI seizures enhanced post-seizure hippocampal CA1 neuron loss.
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Levetiracetam reduces hippocampal neuron loss after early post-FPI seizure.