Distinct Role of Surface Lymphotoxin Expressed by B Cells in the Organization of Secondary Lymphoid Tissues

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• 作者：Alexei V. Tumanov ; Dmitry V. Kuprash ; Maria A. Lagarkova ; Sergei I. Grivennikov ; Koichiro Abe ; Alexander N. Shakhov ; Ludmila N. Drutskaya ; Colin L. Stewart ; Alexander V. Chervonsky and Sergei A. Nedos
• 刊名：Immunity
• 出版年：2002
• 出版时间：September 2002
• 年：2002
• 卷：17
• 期：3
• 页码：239-250
• 全文大小：618 K

文摘

In order to definitively ascertain the functional contribution of lymphotoxin (LT) expressed by B cells, we produced mice with the LTβ gene deleted from B cells (B-LTβ KO mice). In contrast to systemic LTβ deletion, in B-LTβ KO mice only splenic microarchitecture was affected, while lymph nodes and Peyer's patches (PP) were normal, except for PP's reduced size. Even though B-LTβ KO spleens retained a small number of follicular dendritic cells (FDC) which appeared to be dependent on LTβ produced by T cells, IgG responses to sheep red blood cells were markedly reduced. Thus, the organogenic function of B-LTβ is almost entirely restricted to spleen, where it supports the correct lymphoid architecture that is critical for an effective humoral immune response.