Lipopolysaccharide-binding protein is bound and internalized by host cells and colocalizes with LPS in the cytoplasm: Implications for a role of LBP in intracellular LPS-signaling
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- 作者：Franziska Kopp ; Sarah Kupsch ; Andra B. Schromm ; aschromm@fz-borstel.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：CD14 ; cluster of differentiation 14 ; CHOL ; cholesterol ; CRP ; C-reactive protein ; DOPC ; 1 ; 2-dioleoyl-sn-glycero-3-phosphocholine ; FI ; fluorescence intensity ; GM1 ; gangliosid M1 ; LBP ; lipopolysaccharide-binding protein ; LBPA488 ; Alexa Fluor 488-conjugated LBP ; LBPA647 ; Alexa Fluor 647-conjugated LBP ; LPS ; lipopolysaccharide ; MNC ; mononuclear cells ; MD-2 ; myeloid-differentiation factor-2 ; NBD-PE ; N-(7-nitro-2 ; 1 ; 3-benzoxadiazol-4-yl)-PE ; Rh-PE ; N-(rhodamine B sulfonyl)-PE ; SM ; sphingomyelin ; TLR4 ; T
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1863
- 期：4
- 页码：660-672
- 全文大小：3172 K
文摘
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LBP interacts with the cytoplasmic membrane of host cells.
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LBP is internalized by human host cells.
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LBP is involved in intracellular LPS trafficking.
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Potential mechanism for the delivery of LPS to intracellular pattern recognition receptors