Hyperglycemia alters refractory periods in human diabetic neuropathy

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• 作者：Misawa ; Sonoko ; Kuwabara ; Satoshi ; Ogawara ; Kazue ; Kitano ; Yukiko ; Yagui ; Kazuo ; Hattori ; Takamichi
• 关键词：Diabetic neuropathy ; Refractory period ; Refractoriness ; Sodium channel
• 刊名：Clinical Neurophysiology
• 出版年：2004
• 出版时间：November, 2004
• 年：2004
• 卷：115
• 期：11
• 页码：2525-2529
• 全文大小：122 K

文摘

Objective: To investigate the effects of hyperglycemia on axonal excitability in human diabetics. Diabetic nerve dysfunction is partly associated with the altered polyol pathway and Na⁺–K⁺ ATPase activity, probably resulting in a decrease in the trans-axonal Na⁺ gradient and reduced nodal Na⁺ currents.