Decursin inhibits osteoclastogenesis by downregulating NFATc1 and blocking fusion of pre-osteoclasts
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- 作者：Kwang-Jin Kima ; 1 ; Jeong-Tae Yeonb ; 1 ; Sik-Won Choic ; Seong-Hee Moonc ; d ; Byung Jun Ryuc ; Ri Yue ; Sang-Joon Parke ; Seong Hwan Kimc ; hwan@krict.re.kr" class="auth_mail" title="E-mail the corresponding author ; Young-Jin Sona ; sony@sunchon.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 刊名：Bone
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：81
- 期：Complete
- 页码：208-216
- 全文大小：1002 K
文摘
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Decursin inhibits osteoclastogenesis by blocking the expression of NFATc1.
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Decursin decreases the fusion and migration of pre-osteoclasts through down-regulated DC-STAMP and β3 integrin by reduced NFATc1.
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Decursin could provide benefits for the treatment of some kind of bone diseases in the clinical aspect.
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