L-Tryptophan-kynurenine pathway enzymes are therapeutic target for neuropsychiatric diseases: Focus on cell type differences

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• 作者：Hidetsugu Fujigaki^a ; ^{h-fuji@hs.hirokoku-u.ac.jp} ; Yasuko Yamamoto^b ; Kuniaki Saito^b ; ^c
• 关键词：Kynurenine pathway ; Indoleamine 2 ; 3-dioxygenase ; Kynurenine 3-monooxygenase ; Kynurenine aminotransferase ; Kynurenine ; Kynurenic acid ; Quinolinic acid
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：112
• 期：part_PB
• 页码：264-274
• 全文大小：1035 K
• 卷排序：112

文摘

The kynurenine pathway (KP) is associated with neurological diseases because several KP metabolites are neuroactive. The KP enzymes show cell-type specific expression. KP manipulation by KP enzyme inhibition is a potential therapeutic strategy for neurological diseases.