Small Molecules Facilitate Single Factor-Mediated Hepatic Reprogramming
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- 作者：Kyung Tae Lim1 ; Seung Chan Lee1 ; 10 ; Yimeng Gao5 ; Kee-Pyo Kim2 ; Guangqi Song3 ; Su Yeon An4 ; Kenjiro Adachi2 ; Yu Jin Jang4 ; Jonghun Kim1 ; Kyoung-Jin Oh6 ; Tae Hwan Kwak1 ; Seon In Hwang1 ; 10 ; Jueng Soo You7 ; Kinarm Ko1 ; Seung-Hoi Koo6 ; Amar Deep Sharma3 ; Jong-Hoon Kim4 ; Lijian Hui5 ; Tobias Cantz2 ; 3 ; Hans R. Schö ; ler1 ; 2 ; 8 ; Dong Wook Han1 ; 9 ; 10 ; dwhan@konkuk.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：direct conversion ; induced hepatocytes ; conversion kinetics ; MET
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：26 April 2016
- 年：2016
- 卷：15
- 期：4
- 页码：814-829
- 全文大小：7801 K
文摘
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Direct conversion process toward iHeps is a sequential transition
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MET activation facilitates the robust iHep generation in mouse and human
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Hnf1α alone is sufficient for hepatic conversion in the presence of small molecules
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Hnf1α-derived iHeps represent the more mature hepatic state