Treadmill exercise facilitates synaptic plasticity on dopaminergic neurons and fibers in the mouse model with Parkinson’s disease
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- 作者：Mal-Soon Shina ; Ho-Young Jeongb ; Da-In Anb ; Hye-Yun Leeb ; Yun-Hee Sungb ; sungpt97@kyungnam.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：PD ; Parkinson&rsquo ; s disease ; MPTP ; 1-methyl-4-phenyl-l ; 2 ; 3 ; 6-tetrahydropyridine ; TH ; tyrosine hydroxylase ; PSD-95 ; post-synaptic density protein 95 ; SNpc ; substantia nigra pars compacta
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：16 May 2016
- 年：2016
- 卷：621
- 期：Complete
- 页码：28-33
- 全文大小：2052 K
文摘
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Treadmill exercise increased decreased motor balance and coordination ability in mouse models of Parkinson’s disease (PD).
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Treadmill exercise increased level of tyrosine hydroxylase on the substantia nigra pars compacta and striatum in mouse models of PD.
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Treadmill exercise facilitated expression of PSD-95 and synaptophysin and increased dendritic spines on dopaminergic neurons and fibers in mouse models of PD.