Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans

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• 作者：Suk-Kyun Yang¹ ; ^&lowast ; ; Myunghee Hong² ; ^&lowast ; ; Hyunjung Oh² ; Hui-Qi Low² ; Seulgi Jung² ; Seonjoo Ahn² ; Youngjin Kim² ; Jiwon Baek² ; Cue Hyunkyu Lee³ ; ⁴ ; Eunji Kim³ ; ⁴ ; ⁵ ; Kyung Mo Kim⁶ ; Byong Duk Ye¹ ; Kyung-Jo Kim¹ ; Sang Hyoung Park¹ ; Ho-Su Lee¹ ; Inchul Lee⁷ ; Hyoung Doo Shin⁸ ; Buhm Han³ ; ⁴ ; Dermot P.B. McGovern⁹ ; Jianjun Liu¹⁰ ; Kyuyoung Song² ; ^{kysong@amc.seoul.kr}
• 关键词：Crohn&rsquo ; s Disease ; Ulcerative Colitis ; Genetics ; Risk Factor
• 刊名：Gastroenterology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：151
• 期：6
• 页码：1096-1099.e4
• 全文大小：864 K
• 卷排序：151

文摘

Recent genome-wide association studies have identified more than 200 regions that affect susceptibility to inflammatory bowel disease (IBD). However, identified common variants account for only a fraction of IBD heritability and largely have been identified in populations of European ancestry. We performed a genome-wide association study of susceptibility loci in Korean individuals, comprising a total of 1505 IBD patients and 4041 controls. We identified 2 new susceptibility loci for IBD at genome-wide significance: rs3766920 near PYGO2-SHC1 at 1q21 and rs16953946 in CDYL2 at 16q23. In addition, we confirmed associations, in Koreans, with 28 established IBD loci (P < 2.16 × 10-4). Our findings support the complementary value of genetic studies in different populations.