Exposure of isoflurane-treated cells to hyperoxia decreases cell viability and activates the mitochondrial apoptotic pathway
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- 作者：Gunn Hee Kima ; Jeong Jin Leeb ; ljj6625@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sang Hyun Leeb ; Yang Hoon Chungb ; Hyun Sung Chob ; Jie Ae Kimb ; Min Kyung Kimc
- 关键词：Alzheimer׳s disease
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：1636
- 期：Complete
- 页码：13-20
- 全文大小：1372 K
文摘
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The effects of hyperoxia on rat PC12 cells that were exposed to isoflurane.
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Isoflurane decrease cell viability in a dose- and time-dependent manner.
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This effect is augmented by hyperoxia.
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ROS, mitochondrial apoptotic signaling pathway, and β-amyloid may be involved.