Prolonged hyperinsulinemia affects metabolic signal transduction markers in a tissue specific manner
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- 作者：A. Campolo ; M.A. de Laat&dagger ; ; L. Keith ; K.J. Gruntmeir ; V.A. Lacombe ; veronique.lacombe@okstate.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Insulin signaling ; Glucose transporter ; Insulin receptor ; Laminitis ; Horse
- 刊名：Domestic Animal Endocrinology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：55
- 期：Complete
- 页码：41-45
- 全文大小：474 K
文摘
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We used a unique equine model of prolonged hyperinsulinemia–induced laminitis.
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Hyperinsulinemia increased cardiac insulin-signaling marker and glucose transporter gene expression.
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Hyperinsulinemia did not alter metabolic signal transduction markers in the lamellae.
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Discrepant findings between insulin-sensitive and insulin-independent tissues.