The cytotoxicity of BAMLET complexes is due to oleic acid and independent of the α-lactalbumin component
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- 作者：Yamixa Delgadoa ; Moraima Morales-Cruza ; Cindy M. Figueroab ; José ; Herná ; ndez-Romá ; na ; Glinda Herná ; ndeza ; Kai Griebenowa ; b ; kai.griebenow@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：α-LA ; α-lactalbumin ; BAMLET ; bovine α-lactalbumin made lethal to tumor cells ; DLS ; dynamic light scattering ; EPR ; enhanced permeability and retention ; FA ; fatty acid ; FoA ; folic acid ; HAMLET ; human α-lactalbumin made lethal to tumor cells ; MTS ; 3-(4 ; 5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium ; NP ; nanoparticles ; OA ; oleic acid ; PMS ; phenazine methosulfate ; SEM ; scanning electron microscopy
- 刊名：FEBS Open Bio
- 出版年：2015
- 出版时间：2015
- 年：2015
- 卷：5
- 期：Complete
- 页码：397-404
- 全文大小：1540 K
文摘
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We synthesized three different BAMLET complexes consisting of oleic acid coupled to bovine α-lactalbumin.
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Oleic acid micelles alone are tumoricidal at equimolar concentrations of oleic acid bound in the BAMLET complexes.
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α-Lactalbumin is non-toxic to cells even when delivered to their cytoplasm.
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Both, BAMLET and oleic acid micelles showed no selective cytotoxicity to cancer cells.
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