The metabolic trinity, glucose-glycogen-lactate, links astrocytes and neurons in brain energetics, signaling, memory, and gene expression

详细信息    查看全文

• 作者：Gerald A. Dienel ; ^{gadienel@uams.edu}
• 关键词：ANL ; astrocyte-to-neuron lactate ; A-V ; arteriovenous difference ; CBF ; cerebral blood flow rate ; CMR ; cerebral metabolic rate ; 4-CIN ; α-cyano-4-hydroxycinnamate ; DAB ; 1 ; 4-dideoxy-1 ; 4-amino-d-arabinitol ; glc ; glucose ; HCAR1 ; hydroxycarboxylic acid receptor1 ; GPR81 ; G-protein-coupled lactate receptor81 ; lac ; lactate ; OGI ; oxygen glucose index ; OCI ; oxygen carbohydrate index ; MCT ; monocarboxylic acid transporter
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：637
• 期：Complete
• 页码：18-25
• 全文大小：1017 K
• 卷排序：637

文摘

Glucose, glycogen, and lactate are involved in diverse aspects of brain function. Fate of surplus carbohydrate taken up into brain during exercise is unexplained. Glucose and lactate enhance memory; glycogen is required for its consolidation. High-dose lactate preserves memory and gene expression without glycogenolysis. High-dose lactate suppresses neuronal firing and is taken up mainly by astrocytes.