A low-cost flexible pH sensor array for wound assessment

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• 作者：Rahim Rahimi^a ; ^bAuthor Vitae ; Manuel Ochoa^a ; ^bAuthor Vitae ; Tejasvi Parupudi^a ; ^b ; Xin Zhao^c ; ^d ; Iman K. Yazdi^c ; ^d ; Mehmet R. Dokmeci^c ; ^dAuthor Vitae ; Ali Tamayol^c ; ^d ; Ali Khademhosseini^c ; ^d ; ^e ; ^f ; ^gAuthor Vitae ; Babak Ziaie^a ; ^b ; ^{bziaie@purdue.edu" class="auth_mail" title="E-mail the corresponding author}Author Vitae
• 关键词：Chronic wound ; pH sensing array ; Paper substrates ; Rapid prototyping ; Laser micromachining
• 刊名：Sensors & Actuators: B. Chemical
• 出版年：2016
• 出版时间：28 June 2016
• 年：2016
• 卷：229
• 期：Complete
• 页码：609-617
• 全文大小：2582 K

文摘

The pH level in a chronic wound bed is a key indicative parameter for assessment of the healing progress. Due to fragility and inability to measure multiple wound regions simultaneously, commercial glass microelectrodes are not well-suited for spatial mapping of the wound pH. To address this issue, we present an inexpensive flexible array of pH sensors fabricated on a polymer-coated commercial paper (palette paper). Each sensor consists of two screen-printed electrodes, an Ag/AgCl reference electrode and a carbon electrode coated with a conductive proton-selective polymeric (polyaniline, PANI) membrane. Laser-machining is used to create a self-aligned passivation layer with access holes that is bonded over the sensing and reference electrodes by lamination technology. Characterization of the pH sensors reveal a linear (r² = 0.9734) relationship between the output voltage and pH in the 4–10 pH range with an average sensitivity of −50 mV/pH. The sensors feature a rise and fall time of 12 and 36 s for a pH swing of 8-6-8. The sensor biocompatibility is confirmed with human kertinocyte cells.