Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection
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- 作者：Andrew I. Flyak1 ; Xiaoli Shen5 ; Charles D. Murin8 ; 9 ; Hannah L. Turner8 ; Joshua A. David8 ; Marnie L. Fusco9 ; Rebecca Lampley3 ; Nurgun Kose3 ; Philipp A. Ilinykh5 ; Natalia Kuzmina5 ; Andre Branchizio3 ; Hannah King3 ; Leland Brown3 ; Christopher Bryan11 ; Edgar Davidson11 ; Benjamin J. Doranz11 ; James C. Slaughter3 ; 4 ; Gopal Sapparapu3 ; Curtis Klages7 ; Thomas G. Ksiazek5 ; 6 ; 7 ; Erica Ollmann Saphire9 ; 10 ; Andrew B. Ward8 ; Alexander Bukreyev5 ; 6 ; 7 ; alexander.bukreyev@utmb.edu" class="auth_mail" title="E-mail the corresponding author ; James E. Crowe Jr.1 ; 2 ; 3 ; james.crowe@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：28 January 2016
- 年：2016
- 卷：164
- 期：3
- 页码：392-405
- 全文大小：1905 K
文摘
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id="p0010">Natural Ebolavirus infection induced B cells encoding cross-reactive antibodies
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id="p0015">Some cross-reactive human antibodies neutralized multiple Ebolavirus species
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id="p0020">A large proportion of BDBV-neutralizing antibodies bound to the glycan cap
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id="p0025">Glycan cap-specific antibodies exhibited very potent neutralizing activity