Medium redesign for stable cultivation and high production of mevalonate by recombinant Methtylobacterium extorquens AM1 with mevalonate synthetic pathway

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• 作者：Lan-Yu Cui ; Wei-Fan Liang ; Wen-Liang Zhu ; Ming-Yang Sun ; Chong Zhang ; ^{chongzhang@tsinghua.edu.cn} ; ^{zhangchong.thu@gmail.com} ; Xin-Hui Xing
• 关键词：Methylobacterium extorquens AM1 ; Mevalonic acid ; Stable growth ; Methanol
• 刊名：Biochemical Engineering Journal
• 出版年：2017
• 出版时间：15 March 2017
• 年：2017
• 卷：119
• 期：Complete
• 页码：67-73
• 全文大小：895 K
• 卷排序：119

文摘

A cheap, effective medium was developed for stable cell growth. Cell-to-cell heterogeneity confirmed that the medium support stable cell growth. The highest MEV titer productivity yet reported for AM1 was obtained.