Evaluation of functional single nucleotide polymorphisms of different genes coding for the immunoregulatory molecules in patients with monoclonal large granular lymphocyte lymphocytosis

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• 作者：Pilar Garrido ; Julia Almeida ; Jose Marí ; a Romero ; Julia Cantó ; n ; Yorick S ; berg ; Paloma Bá ; rcena ; Margarida Lima ; Anton W. Langerak ; Alberto Orfao ; Francisco Ruiz-Cabello
• 关键词：Polymorphism ; Monoclonal expansions ; LGL ; Lymphocytosis
• 刊名：Human Immunology
• 出版年：2008
• 出版时间：February 2008
• 年：2008
• 卷：69
• 期：2
• 页码：101-107
• 全文大小：398 K

文摘

TCRwww.sciencedirect.com/scidirimg/entities/204e.gif"" alt=""greek small letter alpha"" title=""greek small letter alpha"" border=""0"">β⁺/CD4⁺ T–large granular lymphocyte (LGL) lymphocytosis is a subgroup of monoclonal T-LGL lymphoproliferative disorders that are different from the CD8⁺ TCRwww.sciencedirect.com/scidirimg/entities/204e.gif"" alt=""greek small letter alpha"" title=""greek small letter alpha"" border=""0"">βT-LGL. An increasing evidence supports the involvement of a common antigen-driven mechanism in the etiology of TCRwww.sciencedirect.com/scidirimg/entities/204e.gif"" alt=""greek small letter alpha"" title=""greek small letter alpha"" border=""0"">β⁺/CD4⁺ T-LGL. In this study, we tested several polymorphic markers associated with chronic viral infections and autoimmune diseases, including cytotoxic T-lymphocyte antigen–4 (CTLA-4), tumor necrosis factor–www.sciencedirect.com/scidirimg/entities/204e.gif"" alt=""greek small letter alpha"" title=""greek small letter alpha"" border=""0""> (TNF-www.sciencedirect.com/scidirimg/entities/204e.gif"" alt=""greek small letter alpha"" title=""greek small letter alpha"" border=""0"">), interleukin-10 (IL-10), interferon-γ (IFN-γ), RANTES, IL-1www.sciencedirect.com/scidirimg/entities/204e.gif"" alt=""greek small letter alpha"" title=""greek small letter alpha"" border=""0"">, FAS, FAS-ligand (FASL), and NKG2D, to investigate the potential association of these immunogenetic factors with the development of T-LGL. Overall, 38 patients with CD4⁺ T-LGL were analyzed and compared with a group of both CD8⁺/TCRwww.sciencedirect.com/scidirimg/entities/204e.gif"" alt=""greek small letter alpha"" title=""greek small letter alpha"" border=""0"">β⁺ T-LGL patients (n = 43) and a group of control subjects (n = 176). Our results did not show any clear association between the different single nucleotide polymorphisms (SNPs) analyzed and the development of CD4⁺/TCRwww.sciencedirect.com/scidirimg/entities/204e.gif"" alt=""greek small letter alpha"" title=""greek small letter alpha"" border=""0"">β T-LGL. An increase in the frequency of −380 (AA/GA) TNF-www.sciencedirect.com/scidirimg/entities/204e.gif"" alt=""greek small letter alpha"" title=""greek small letter alpha"" border=""0""> genotype associated with a greater production of this cytokine was found among CD8⁺ T LGL patients in comparison to the CD4⁺LGL patients and the control group. Our results suggest that the frequency of SNP of the genes coding for the studied immunoregulatory molecules are not associated with the development of CD4⁺/TCRwww.sciencedirect.com/scidirimg/entities/204e.gif"" alt=""greek small letter alpha"" title=""greek small letter alpha"" border=""0"">β⁺ T-LGL.