Household Consumption of Thiamin-Fortified Fish Sauce Increases Erythrocyte Thiamin Concentrations among Rural Cambodian Women and Their Children Younger Than 5 Years of Age: A Randomized Controlled Efficacy Trial

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• 作者：Kyly C. Whitfield ; PhD¹ ; ² ; Crystal D. Karakochuk ; MSc² ; Hou Kroeun ; MPH³ ; Ly Sokhoing ; MPH³ ; Benny B. Chan ; BSc² ; Mam Borath ; MMgt⁴ ; Prak Sophonneary ; MD⁵ ; Kirsten Moore ; BA² ; Jeffery K.T. Tong ; BSc² ; Judy McLean ; PhD² ; Aminuzzaman Talukder ; MPH³ ; Larry D. Lynd ; PhD⁶ ; Eunice C.Y. Li-Chan ; PhD² ; David D. Kitts ; PhD² ; Tim J. Green ; PhD² ; ⁷ ; ⁸ ; ^{tim.green@sahmri.com}
• 关键词：maternal and child health ; thiamin ; fortification ; fish sauce ; Southeast Asia
• 刊名：The Journal of Pediatrics
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：181
• 期：Complete
• 页码：242-247.e2
• 全文大小：991 K
• 卷排序：181

文摘

To assess whether ad libitum consumption of thiamin-fortified fish sauce over 6 months yields higher erythrocyte thiamin diphosphate concentrations (eTDP) among women of childbearing age and their children aged 12-59 months compared with control sauce containing no thiamin.Study designIn this double-blind, randomized controlled efficacy trial, 276 nonpregnant, nonlactating women (18-45 years of age) and their families in Prey Veng, Cambodia, were randomized to receive 1 of 3 fish sauce formulations: low thiamin concentration (low, 2 g/L), high thiamin concentration (high, 8 g/L), or a control (no thiamin) fish sauce. Baseline (t = 0) and endline (t = 6 months) eTDP were measured with the use of high-performance liquid chromatography with a fluorescence detector.ResultsFish sauce consumption did not differ between treatment groups (P = .19). In intent-to-treat analysis, women's baseline-adjusted endline eTDP (mean; 95% CI) was higher among women in the low (259; 245-274 nmol/L) and high (257; 237-276 nmol/L) groups compared with control (184; 169-198 nmol/L; P < .001); low and high groups did not differ (P = .83). Similarly, children's baseline-adjusted eTDP was higher in the low (259; 246-271 nmol/L) and high (257; 243-270 nmol/L) groups compared with control (213; 202-224 nmol/L; P < .001).ConclusionFortified fish sauce appears to be an efficacious means of improving biochemical thiamin status in nonpregnant, nonlactating women and their children (1-5 years of age) living in rural Cambodia.Trial registrationClinicalTrials.gov: NCT02221063.