Thrombectomy for Acute Stroke in Childhood: A Case Report, Literature Review, and Recommendations

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• 作者：Maria Celeste Buompadre ; MD^a ; Kathleen Andres ; MN ; NP-Paediatrics^a ; Lee-Anne Slater ; MD^b ; ^c ; Hadi Mohseni-Bod ; MD ; FMGEMS ; USML ; MRCPCH^d ; Anne-Marie Guerguerian ; MD ; FAAP ; FRCPC^d ; Helen Branson ; BSc ; MBBS ; FRANZCR^e ; Suzanne Laughlin ; MD ; FRCP(C)^e ; Derek Armstrong ; MB ; BS ; FRCP(C)^e ; Mahendranath Moharir ; MD^a ; Gabrielle deVeber ; MD^a ; Tilman Humpl ; MD ; PhD^d ; Osami Honjo ; MD ; PhD^f ; Shaf Keshavjee ; MD ; MSc ; FRCSC ; FACS^g ; Rebecca Ichord ; MD^h ; Vitor Pereira ; MD ; MSc^b ; ^c ; Nomazulu Dlamini ; MD^a ; ^{nomazulu.dlamini@sickkids.ca}
• 关键词：pediatric stroke ; stroke ; treatment ; mechanical thrombectomy ; embolectomy ; endovascular procedures ; interventional lung-assist device ; oxygenators
• 刊名：Pediatric Neurology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：66
• 期：Complete
• 页码：21-27
• 全文大小：710 K
• 卷排序：66

文摘

The updated American Heart Association/American Stroke Association guidelines include recommendation for thrombectomy in certain adult stroke cases. The safety and efficacy of thrombectomy in children are unknown. An 8-year-old girl experienced acute stroke symptoms on two occasions while therapeutically anticoagulated on Novalung. Computed tomography scans showed proximal vessel thrombi, which were retrieved using a Trevo device without hemorrhagic complications. Postprocedural assessment found respective decreases in the National Institutes of Health Stroke Scale score from 10 to 4 and 12 to 7. The indications for treatment and early benefits observed in our case are consistent with other pediatric thrombectomy cases reported. However, publication bias and the heterogeneity of reported cases prevent drawing conclusions about the safety and efficacy of thrombectomy in children. Anticipating that updates to adult stroke guidelines would likely incite stroke providers to consider thrombectomy in children, our institution developed guidelines for thrombectomy before the index patient. Establishing institutional guidelines before considering thrombectomy in children may optimize patient safety.