EBF2 Regulates Osteoblast-Dependent Differentiation of Osteoclasts

详细信息    查看全文

• 作者：Matthias Kieslinger ; Stephanie Folberth ; Gergana Dobreva ; Tatjana Dorn ; Laura Croci ; Reinhold Erben ; G. Giacomo Consalez ; Rudolf Grosschedl
• 关键词：CELLBIO ; CELLCYCLE
• 刊名：Developmental Cell
• 出版年：2005
• 出版时间：December 2005
• 年：2005
• 卷：9
• 期：6
• 页码：757-767
• 全文大小：867 K

文摘

Communication between bone-depositing osteoblasts and bone-resorbing osteoclasts is required for bone development and homeostasis. Here, we identify EBF2, a member of the early B cell factor (EBF) family of transcription factors that is expressed in osteoblast progenitors, as a regulator of osteoclast differentiation. We find that mice homozygous for a targeted inactivation of Ebf2 show reduced bone mass and an increase in the number of osteoclasts. These defects are accompanied by a marked downregulation of the osteoprotegerin (Opg) gene, encoding a RANK decoy receptor. EBF2 binds to sequences in the Opg promoter and transactivates the Opg promoter in synergy with the Wnt-responsive LEF1/TCF:β-catenin pathway. Taken together, these data identify EBF2 as a regulator of RANK-RANKL signaling and osteoblast-dependent differentiation of osteoclasts.