Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth
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- 作者：Jinghe Huang1 ; 8 ; Byong H. Kang1 ; 8 ; Elise Ishida1 ; 8 ; Tongqing Zhou2 ; 8 ; Trevor Griesman1 ; Zizhang Sheng4 ; Fan Wu3 ; Nicole A. Doria-Rose2 ; Baoshan Zhang2 ; Krisha McKee2 ; Sijy O&rsquo ; Dell2 ; Gwo-Yu Chuang2 ; Aliaksandr Druz2 ; Ivelin S. Georgiev5 ; 6 ; 7 ; Chaim A. Schramm4 ; Anqi Zheng2 ; M. Gordon Joyce2 ; Mangaiarkarasi Asokan2 ; Amy Ransier2 ; Sam Darko2 ; Stephen A. Migueles1 ; Robert T. Bailer2 ; Mark K. Louder2 ; S. Munir Alam6 ; Robert Parks6 ; Garnett Kelsoe6 ; Tarra Von Holle6 ; Barton F. Haynes6 ; Daniel C. Douek2 ; Vanessa Hirsch3 ; Michael S. Seaman7 ; Lawrence Shapiro2 ; 4 ; John R. Mascola2 ; Peter D. Kwong2 ; Mark Connors1 ; 9 ; mconnors@nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：HIV ; neutralizing ; antibody ; CD4-binding site ; vaccine ; immunotherapy ; prophylaxis ; resistance ; envelope ; structure
- 刊名：Immunity
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：45
- 期：5
- 页码：1108-1121
- 全文大小：5435 K
文摘
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CD4bs antibody N6 potently neutralizes 98% of HIV isolates
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N6 potently neutralizes isolates resistant to other CD4bs antibodies
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N6 evolved from an early intermediate within a VRC01-class antibody lineage
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Unique structural features circumvent mechanisms of resistance to the VRC01 class