Improved anticancer and antiparasitic activity of new lawsone Mannich bases

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• 作者：Katharina Mahal^a ; ¹ ; Aamir Ahmad^b ; ¹ ; Florian Schmitt^a ; Julia Lockhauserbä ; umer^c ; Kathrin Starz^c ; Rohan Pradhan^d ; Subhash Padhye^d ; Fazlul H. Sarkar^b ; Waleed S. Koko^e ; ^f ; Rainer Schobert^a ; Klaus Ersfeld^c ; Bernhard Biersack^a ; ^{bernhard.biersack@yahoo.com}
• 关键词：Lawsone ; Mannich base ; Anticancer drugs ; Antiparasitic drugs
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：27 January 2017
• 年：2017
• 卷：126
• 期：Complete
• 页码：421-431
• 全文大小：1123 K
• 卷排序：126

文摘

New fatty alkyl substituted lawsone Mannich bases were prepared. 2a–c showed strong and selective tumor cell growth inhibition. 2a–c exhibited sub-micromolar activity against T. b. brucei cells. 2a–c caused strong deformation of the T. b. brucei cytoskeleton. 2c revealed stronger antiamoebic activity than metronidazole.