Increasing in cysteine proteinase B expression and enzymatic activity during in vitro differentiation of Leishmania (Viannia) braziliensis: First evidence of modulation during morphological transition

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• 作者：Cinthia Bernardes Gomes^a ; ¹ ; Franklin Souza -Silva^a ; ¹ ; Karen dos Santos Charret^a ; ¹ ; Bernardo Acá ; cio Santini Pereira^a ; Lé ; a Cysne Finkelstein^b ; Raquel Santos-de-Souza^a ; Luzia Monteiro de Castro Cô ; rtes^a ; Mirian Claudia Souza Pereira^c ; Francisco Odê ; ncio Rodrigues de Oliveira Jr.^c ; Carlos Roberto Alves^a ; ^{calves@ioc.fiocruz.br}
• 关键词：Leishmania (Viannia) braziliensis ; Cysteine proteinases B ; Cathepsin L ; Z-Phe-Arg 7-amido-4-methylcoumarin hydrochloride ; Z-Phe-Phe-fluoromethyl ketoneand ; Trans-epoxysuccinyl-l-leucylamido(4-guanidino)butane
• 刊名：Biochimie
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：133
• 期：Complete
• 页码：28-36
• 全文大小：1325 K
• 卷排序：133

文摘

Increase of cathepsin L-like during in vitro differentiation of L. (V.) braziliensis. Modulation of cathepsin L-like in L. (V.) braziliensis by pH and temperature. LbrM.08.0820/LbrM.08.0830 genes present expression profiles similar to LbrM.08.0810 Proteolytic activity is increased along differentiation by cathepsin-like.