Exercise modulates the aortic renin-angiotensin system independently of estrogen therapy in ovariectomized hypertensive rats

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• 作者：Patrick W. Endlich^a ; ^b ; Erick R.G. Claudio^a ; Leandro C.F. Lima^c ; Rog&eacute ; rio F. Ribeiro Jú ; nior^a ; Antonio A.B. Peluso^c ; Ivanita Stefanon^a ; Nazar&eacute ; S. Bissoli^a ; Virginia S. Lemos^c ; Robson A.S. dos Santos^c ; Glaucia R. de Abreu^a ; ^{abreugr1994@gmail.com}
• 关键词：ACE ; angiotensin converting enzyme ; Ach ; acetylcholine ; ANG II ; angiotensin II ; ANG-(1-7) ; angiotensin (1-7) ; ANOVA ; analysis of variance ; ANP ; atrial natriuretic peptide ; AT1 ; angiotensin type 1 receptor ; AT2 ; angiotensin type 2 receptor ; CVD ; cardiovascular disease ; E2 ; 17β-estradiol ; ET ; estrogen therapy ; gp91phox ; phagocytic oxidase 91 ; KCl ; potassium chloride ; L-NAME ; L-nitro arginine methyl esther ; Mas ; angiotensin (1-7) G protein coupled-receptor ; mRNA ; messenger ribonucleic acid ; NADPH
• 刊名：Peptides
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：87
• 期：Complete
• 页码：41-49
• 全文大小：1862 K
• 卷排序：87

文摘

Some components of the renin-angiotensin system (RAS) are altered under conditions of estrogen deficiency and hypertension. Exercise training reverses the detrimental effects of ovariectomy on the aortic reactivity to ANG II and ANG-(1-7) in hypertensive rats. Exercise training modulates RAS independently of estrogen therapy, protecting the hypertensive postmenopausal women against CVD.