Structural and binding studies of a C-type galactose-binding lectin from Bothrops jararacussu snake venom

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• 作者：Marco A. Sartim^a ; ¹ ; Matheus P. Pinheiro^b ; ¹ ; Ricardo A.P. de Pá ; dua^b ; ¹ ; Suely V. Sampaio^a ; M. Cristina Nonato^b ; ^{cristy@fcfrp.usp.br}
• 关键词：Snake venom ; Galactoside-binding lectin ; Bothrops jararacussu ; X-ray crystallography ; Thermofluor
• 刊名：Toxicon
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：126
• 期：Complete
• 页码：59-69
• 全文大小：2634 K
• 卷排序：126

文摘

BJcuL is a snake venom galactoside-binding lectin isolated from Bothrops jararacussu. The structure of holo BJcuL was determined by X-ray crystallography. BJcuL structure revealed the existence of a porous and flexible decameric arrangement. A novel BJcuL binding site for the gentamicin group of antibiotics was predicted. Insights into structural behavior and functional diversification of BjcuL were provided.