A Polymorphic Antioxidant Response Element Links NRF2/sMAF Binding to Enhanced MAPT Expression and Reduced Risk of Parkinsonian Disorders
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- 作者：Xuting Wang1 ; wang21@niehs.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Michelle R. Campbell1 ; Sarah E. Lacher2 ; 3 ; Hye-Youn Cho4 ; Ma Wan1 ; Christopher L. Crowl1 ; Brian N. Chorley1 ; 6 ; Gareth L. Bond5 ; Steven R. Kleeberger4 ; Matthew Slattery2 ; 3 ; Douglas A. Bell1 ; bell1@niehs.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：26 April 2016
- 年：2016
- 卷：15
- 期：4
- 页码：830-842
- 全文大小：2692 K
文摘
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Genome-wide NRF2/sMAF occupancy defines highly ranked disease-associated SNPs
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SNPs in NRF2 binding sites are rare in the human genome due to negative selection
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A SNP in MAPT shows allele-specific binding to NRF2, enhanced MAPT transcription
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Strong NRF2 binding site is linked with reduced risk of parkinsonian diseases