A highly sensitive on-off fluorescent chemosensor for Cu²⁺ based on coumarin

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• 作者：Hui-Qin Chang ; Xiao-Lei Zhao ; ^{zhaoxiaolei@hpu.edu.cn} ; Wei-Na Wu ; ^{wuwn08@hpu.edu.cn} ; Lei Jia ; Yuan Wang ; ^{wangyuan08@hpu.edu.cn}
• 关键词：Fluorescent sensor ; coumarin ; Cu2+ ; on-off sensor
• 刊名：Journal of Luminescence
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：182
• 期：Complete
• 页码：268-273
• 全文大小：1829 K
• 卷排序：182

文摘

Chemosensor C1, namely, 3-acetoacetyl-7-hydroxycoumarin, was synthesized and exhibited highly selective and sensitive fluorescence sensing ability for Cu2+ over other metal ions under physiological conditions. The fluorescence quenching response of C1 for Cu2+ indicated that C1 can be used as an on-off fluorescent chemosensor to selectively detect Cu2+. The binding process was confirmed by UV–vis absorption, fluorescence measurement, mass spectroscopy, IR spectra and DFT calculation. To test the practical use of the probe, the determination of Cu2+ in real water samples was evaluated. The application of the fluorescent probe in monitoring intracellular Cu2+ in HeLa cells has also been demonstrated.