Borylation of organo halides and triflates using tetrakis(dimethylamino)diboron

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• 作者：Charles S. Bello ; Joachim Schmidt-Leithoff
• 关键词：Borylation ; Suzuki-reaction ; Pd-Catalysis ; C&ndash ; C-bond formation ; Boronic ester
• 刊名：Tetrahedron Letters
• 出版年：2012
• 出版时间：14 November, 2012
• 年：2012
• 卷：53
• 期：46
• 页码：6230-6235
• 全文大小：2224 K

文摘

We report a new in situ borylation method using tetrakis(dimethylamino)diboron, DMA₄B₂, in the presence of a diol. Our method uses standard borylation conditions and readily available Pd-catalysts. The scope of this method includes aryl halides and triflates as well as vinyl halides and triflates. The method successfully works with a broad range of diols, enabling the selection of the best boronic ester for subsequent Suzuki coupling.