Novel roles of androgen receptor, epidermal growth factor receptor, TP53, regulatory RNAs, NF-kappa-B, chromosomal translocations, neutrophil associated gelatinase, and matrix metalloproteinase-9 in prostate cancer and prostate cancer stem cells

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• 作者：William H. Chappell^a ; ¹ ; Stephen L. Abrams^a ; Kvin Lertpiriyapong^b ; Timothy L. Fitzgerald^c ; Alberto M. Martelli^d ; Lucio Cocco^d ; Dariusz Rakus^e ; Agnieszka Gizak^e ; David Terrian^f ; Linda S. Steelman^a ; James A. McCubrey^a ; ^{mccubreyj@ecu.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：AR ; EGFR ; TP53 ; Regulatory RNAs ; NGAL ; MMP-9
• 刊名：Advances in Biological Regulation
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：60
• 期：Complete
• 页码：64-87
• 全文大小：1864 K

文摘

Approximately one in six men will be diagnosed with some form of prostate cancer in their lifetime. Over 250,000 men worldwide die annually due to complications from prostate cancer. While advancements in prostate cancer screening and therapies have helped in lowering this statistic, better tests and more effective therapies are still needed. This review will summarize the novel roles of the androgen receptor (AR), epidermal growth factor receptor (EGFR), the EGFRvIII variant, TP53, long-non-coding RNAs (lncRNAs), microRNAs (miRs), NF-kappa-B, chromosomal translocations, neutrophil associated gelatinase, (NGAL), matrix metalloproteinase-9 (MMP-9), the tumor microenvironment and cancer stem cells (CSC) have on the diagnosis, development and treatment of prostate cancer.