Aggressive giant cell lesion of the jaws: a review of management options and report of a mandibular lesion treated with denosumab

详细信息    查看全文

• 作者：John Edward O'Connell ; MB ; BDS ; MRCS ; FFD RCSI^a ; ^{Johnedoconnell@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Conor Bowe ; MB BDentSc MFD FFD^a ; Colm Murphy ; MB BDS MFD FFD RCSI^a ; Mary Toner ; MB FRCPath^b ; Gerard J. Kearns ; FFD ; FRCS^c
• 刊名：Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：120
• 期：5
• 页码：e191-e198
• 全文大小：1161 K

文摘

Giant cell lesions (GCLs), previously referred to as giant cell granulomas, are benign tumors of the jaws of unknown etiology. Surgical management of aggressive GCLs is challenging, as these lesions demonstrate a tendency to recur following surgical removal. In addition, surgical treatment can be associated with significant morbidity. In an attempt to reduce both the extent of morbidity and the recurrence rate following surgery, a number of pharmacologic therapies have been advocated on the basis of assumptions about the predominant cell types and receptors, for the management of these lesions.

This report describes the use of denosumab, an agent originally used for its anti-resorptive effects, in the management of an aggressive GCL of the mandible in an older patient, who was unsuitable for extensive surgery and in whom treatment with intralesional triamcinolone had proved unsuccessful. Denosumab may be a viable alternative or adjunct to surgery in the management of GCLs of the jaws.