Anatomical and physiological development of the human inner ear
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- 作者：Rebecca Lim ; Rebecca.Lim@newcastle.edu.au" class="auth_mail" title="E-mail the corresponding author ; Alan M. Brichta
- 关键词：WG ; weeks gestation ; VGNs ; vestibular ganglion neurons ; IHCs ; inner hair cells ; OHCs ; outer hair cells ; SGNs ; spiral ganglion neurons ; GER ; greater epithelial ridge ; LER ; lesser epithelial ridge
- 刊名：Hearing Research
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：338
- 期：Complete
- 页码：9-21
- 全文大小：2023 K
文摘
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Anatomical differentiation of human vestibular hair cells begins by 8 weeks gestation.
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Fetal cochlea hair cell differentiation starts two weeks after vestibular hair cells.
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Afferent innervation of the neuroepithelium occurs before hair cell differentiation.
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Vestibular hair cells and calyx afferent fibers are functional by mid gestation.
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PAX2, SOX2, and SOX9 in human fetal cochlea show graded spatiotemporal profiles.